May be helpful in those with Alzheimer's disease. Acetyl l carnitine protects against amyloid-beta neurotoxicity. It acts as an antioxidant, stimulates neurotransmitter formation, and helps with alertness and improved concentration.
acetyl-L-carnitine - University of Maryland Medical Center
L-acetylcarnitine may help with attention deficit hyperactivity disorder in children with the genetic disorder known as fragile X syndrome. Fragile X syndrome results from an inherited genetic defect on the X chromosome. It is associated with mental retardation and may also cause autism and ADHD, ADHD is common in young boys with fragile X syndrome. Dr. Giovanni Neri from Universita Cattolica in Rome studied boys between 6 and 13 years old for a period one year. Twenty four received l-acetylcarnitine and 27 received placebo. There was a more effective reduction of hyperactivity and improvement of social behavior in treated patients. American Journal of Medical Genetics 2008.
Brain Regions Involved in Fatigue Sensation: reduced acetylcarntine uptake into the brain. Kuratsune, H., Yamaguti, K, Lindh, G, etc. N. Neurol Sci 2004 218: 103-18.
Acetyllcarnitine (abbreviated as ALC or ALCAR) shuttles acetyl groups and fatty acidsinto mitochondria for energy production. Without carnitine, fatty acids cannot easily enter into mitochondria. The acetyl group is used to formacetyl-CoA, the most important intermediary in the generation of energy from amino acids, fats, and carbohydrates. Therefore, acetyl l-carnitine serves as an energy reservoir of acetyl groups and both nutrients help improve energy production. The acetyl group is also used to make the important brain chemical acetylcholine. Some studies suggest that perhaps this nutrient can even act as a neurotransmitter itself.The typical daily dosage for long term use is 100 to 300 mg once a day, preferably in the early part of the day. Acetyl l carnitine side effects include overstimulation, insomnia, and nausea at dosages greater than 500 mg to 1000 mg. If you happen to feel nausea as a side effect, next time just take the capsules with food or take a lesser dose.